Genetic lactase deficiency

Certain changes in DNA, called single nucleotide polymorphisms (SNPs) in the MCM6 (minichromosome maintenance complex component 6) gene have been associated with the most common type of lactose intolerance: physiological lactase deficiency.

We offer a genetic test for the more common genetic mutations associated with lactase deficiency which costs R900.00. All that is needed is a finger prick blood sample to be sent to us for testing. If you are interested in undertaking a genetic lactase deficiency test, please contact us for a kit or go to your nearest Dis-chem or Wellness Warehouse on Kloof (Cape Town).

Note: The ImuPro Food Hypersensitivity test involves testing the protein components of the milk (casein and whey) and will not indicate whether you have lactose intolerance. If you have undertaken the ImuPro test and milk was found to be IgG reactive and you have the symptoms of lactose intolerance, or you would like to test for lactose intolerance, the genetic lactase deficiency test is recommended.


1. S B Matthews, J P Waud, A G Roberts, A K Campbell. Systemic lactose intolerance: a new perspective on an old problem (2005) Postgrad Med J;81:167-173.